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To confirm the histopathologic findings of different forms of central neuropathies (CNP) and further evaluate the expression of synaptophysin (Syn) and some synapse-related proteins in the central nervous system (CNS), and determine the characteristics of Syn-positive processes in these disorders. The study group comprised 41 cases of CNP, including classic Fisher (Fisher's syndrome, FS), acute disseminated encephalomyelitis (ADEM), and Bickerstaff's brainstem encephalitis (BBE). The control group comprised 22 cases of neuromyelitis optica spectrum disorder (NMOSD). The expression of Syn and the distribution of other synaptic proteins in different CNP variants were detected. Syn was expressed mainly in the nerve fibers and dendritic processes of neurons in the white matter of the spinal cord, the cerebral cortex, and the brainstem in FS, ADEM, and BBE cases, which occurred with the presence of edema, demyelinating plaques, vacuolar degeneration, and axonal spheroids. The expression of Syn and other synapse-related proteins in different CNP variants is significantly different from that in NMOSD cases. The regional distribution of Syn in central regions suggests a potential role of Syn in various CNP variants.Slope-based liquidation in health care delivery. The financial management of health care organizations is often inefficient because of a lack of scientific tools in the control of costs. This paper presents a slope-based model (SB model) which, by combining potential outcomes, controlled health care outcomes, and statistical theory, provides a new approach to measuring and managing health care costs. The SB model is defined as an inventory valuation of medical interventions, which can be computed using both cost data and outcome data. The SB model is applied to a hospital's medical and nursing cost centre, whose outcome is a measure of service quality. In the case study, service quality is measured using the Reuter outcome scale, and hospital costs are derived from Medicare's Cost Reports. Using the slopes of the regression function between costs and service quality, interventions are identified that achieve potential cost reductions and cost savings. In addition, the statistical concept of variance shifting is used to measure the cost component of the service quality improvement.With 6 games to go in the regular season, there are few teams 1cb139a0ed
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